7/30/2023 0 Comments Supplements for migraine with aura![]() The question remains as to whether these increased levels of homocysteine relate to migraine, and study results are quite inconsistent. Pooled data from a number of different meta-analysis involving over nine thousand migraine patients and twenty seven thousand controls confirmed a significant association between the T-allele of the gene MTHFR C677T (which reduces the activity of the MTHFR enzyme by up to 50%) and migraine with aura, but is heavily influenced by geography and ethnicity 2 . This causes a condition known as hyperhomocysteinemia, which has been linked to a range of conditions such as atherosclerosis, stroke, osteoporosis, rheumatism, Alzheimer’s and Parkinson’s diseases 1 , and has been inconsistently linked to migraine with aura. There are a number of pieces of evidence demonstrating a link between folate or folic acid and a subset of migraine with aura sufferers: genetic factors, diagnostic tests of a key biomarker, and folic acid supplementation studies.įolate is a key element in the production of nucleotides (building blocks of DNA) and the supply of methyl groups during methionine synthesis by an enzyme called methylenetetrahydrofolate reductase (MTHFR).ĭeficiencies of dietary folate, along with vitamins B6 (pyridoxine) and B12 (cobalamin) or reduced activity of the MTHFR enzyme results in reduced conversion of homocysteine to methionine, leading to a build up of homocysteine levels in the blood. Does folic acid or folate play a role in the cause of migraine? For this reason it is especially important during certain embryonic developmental stages (hence its importance in pregnancy and neural tube defects), but also has been implicated in certain types of cancer. ![]() Folate is required for making DNA, and it is also important in cell division. What is Folic Acid?įolic Acid is the synthetic form of folate (vitamin B9), which plays a critical role in the growth and development of new cells, especially during rapid cell growth. However, folic acid is playing an increasingly important role for a particular group of people with migraine. Folic acid has gained a lot of attention in the past 20 years due to the impact vitamin B9 supplementation during pregnancy has on neural tube defects.
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